The Bible says prior to salvation, all people are dead in sin-- spiritually dead (Ephesians 2:1-3). In this state of death, the sinner is utterly unable to respond to any spiritual stimulus and therefore unable to love God, obey Him, or please Him in any way. Scripture says the mind of every unbeliever "is hostile toward God; for it does not subject itself to the law of God, for it is not even able to do so; and those who are in the flesh cannot please God" (Romans 8:7-8, emphasis added). That describes a state of total hopelessness: spiritual death.--John MacArthur
And you were dead in the trespasses and sins in which you once walked, following the course of this world, following the prince of the power of the air, the spirit that is now at work in the sons of disobedience- among whom we all once lived in the passions of our flesh, carrying out the desires of the body and the mind, and were by nature children of wrath, like the rest of mankind. Eph 2:1-3
For the mind that is set on the flesh is hostile to God, for it does not submit to God's law; indeed, it cannot. Those who are in the flesh cannot please God. Rom 8:7-8
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